Recent Posts

Comparative profiling examines roles of DNA regulatory sequences and accessible chromatin during cold stress response in grasses

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Physical access to regulatory DNA, including cis-regulatory sequences found within proximal promoters and distal enhancer elements, is a vital property of chromatin.  In turn, their access is determined by nucleosome occupancy and post-translational modification of histone proteins. A continuum of chromatin…

Shooting for the STARRs: A Modified STARR-seq Assay for Rapid Identification and Evaluation of Plant Regulatory Sequences in Tobacco Leaves

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A single genome gives rise to different cell types and organs in response to precise temporal and spatial regulation of gene expression, driven by developmental and environmental cues. These expression patterns are orchestrated by cis-regulatory elements, distal enhancers and gene-proximal promoters.…