Recent Posts

Awaking the sleeping carboxylase ($) (JACS)

One of the things I like most about synthetic biology is the “why not” attitude. This article by Bernhardsgrütter et al. is intriguing because rather than taking the standard “let’s fix Rubisco approach,” the authors started with a non-CO2 fixing enzyme and engineered it towards having carboxylase…

A bacterium that demethylates opiate thebaine for a green chemistry solution ($) (Nature Sustainability)

Opium poppies produce opiates including morphine and thebaine. Derivatives of these compounds can also have diverse beneficial properties. One of these, naloxone, is a competitive opioid receptor antagonist that can be administered to counteract the effects of opioid overdose. Because of the rise in…

Addressing fundamental questions in plant science through synthetic biology

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Addressing fundamental questions in plant science through synthetic biology Recorded July 10, 2019  About This Webinar In this seminar, we examined the role that synthetic biology can play in answering fundamental questions in plant science. In studying plants for the past hundred years, we’ve…

Interviews with Synthetic Biologists: Kevin Chen, hyasynth

Synthetic biology is a set of tools, a way of thinking, the integration of engineering principles into biological sciences, and potentially the biggest opportunity for advances in plant sciences since PCR. Yet many struggle to define it, and fewer still grasp its full potential. We have conducted…

Interviews with synthetic biologists: Paul South

Synthetic biology is a set of tools, a way of thinking, the integration of engineering principles into biological sciences, and potentially the biggest opportunity for advances in plant sciences since PCR. Yet many struggle to define it, and fewer still grasp its full potential. Now, four early-career…

Review: Towards a sustainable bio-based economy through plant synthetic biology ($) (Plant Sci)

Plant synthetic biology is heating up, as ideas and methods initially developed for single-celled organisms are moving into the more interesting and complicated space of multicellular organisms; this leads to greater potentials as well as greater challenges. Why plants? One important reason is that they…

Review: Synthetic switches and regulatory circuits in plants (Plant Physiol)

Switches and circuits are key parts of a synthetic biologist’s toolbox. Andres et al. provide historical background and core ideas as well as current understanding of these devices. Switches are defined as components that detect an input signal and transform it into an output signal. Inputs can be…

Review: Applications of protein engineering and directed evolution in plant research (Plant Physiol)

Half of the 2018 Nobel Prize in Chemistry was awarded to Frances Arnold “for the directed evolution of enzymes”. Essentially, this involves modifying an enzyme and screening its properties repeatedly to develop an enzyme with novel attributes.  Engqvist and Rabe review this powerful method and its…

Interviews with synthetic biologists: Karsten Temme, Pivot Bio

Synthetic biology is a set of tools, a way of thinking, the integration of engineering principles into biological sciences, and potentially the biggest opportunity for advances in plant sciences since PCR. Yet many struggle to define it, and fewer still grasp its full potential. Now, four early-career…