Cytokinin modulates context-dependent chromatin accessibility through the type-B response regulators ($) (Nature Plants)

The cytokinin-based response is assumed to be achieved through context-dependent transcriptional regulatory mechanisms. Potter et al. analyzed cytokinin-induced alterations in chromatin accessibility using ATAC-seq (Assay for Transposase-Accessible Chromatin using Sequencing) and combined these results with RNA-seq and  chromatin immunoprecipitation (ChIP)-seq datasets. Their results suggest that differentially accessible regions are adjacent to cytokinin-regulated genes and mostly overlap with type-B ARR ChIP peaks. This article illustrates the dynamics between cytokinin and chromatin to facilitate tissue-specific transcriptional regulation for plant development and stress response. (Summary by Arif Ashraf) Nature Plants 10.1038/s4147-018-0290-y