Recent Posts

In the Histone Zone: The Mighty Eraser

, ,
Histones undergo myriad covalent modifications - more than 100 types have been identified in the 50+ years since Allfrey, Faulkner, and Mirsky (1964) found that increased histone acetylation was associated with genomic regions of active transcription (reviewed in Zentner and Henikoff, 2013). Enzymes…

A Novel Class of Histone Readers

, ,
Polycomb-group (PcG) proteins are part of an epigenetic memory system that regulates global gene expression throughout development in multicellular eukaryotes (Butenko and Ohad, 2011). Sophisticated mechanisms recruit high molecular weight complexes of PcG proteins to specific targets in the genome.…