Tag: Synthetic Biology

Ambitious plant synthetic biology projects are driving the evolution of advanced DNA assembly techniques that permit efficient and rapid assembly of multiple transcriptional units (TUs). Pollack et al. have incorporated features of individual techniques into a single “general purpose DNA assembly…

Samodelov and Zurbriggen describe approaches to exquisitely fine-tune protein and metabolite expression levels through a variety of synthetic and semi-synthetic biology approaches. For example, optigenetics tools enable gene expression to be activated precisely via a light beam; when combined with downstream…

The excellent review by Moses et al. starts by defining the oft-confused terms  metabolite engineering and systems biology. Although systems biology can contribute to the former, it is distinguished by the use of “defined ‘parts’ that are easily combined and exchanged, using standardized workflows…

As photosynthetic autotrophs, plants have the potential to convert sunlight into a vast array of useful products: to act as little green metabolic factories. Of course, they already provide us with everything from carbohydrates and vitamins to stimulants and medicinal compounds, but with a few small…

A healthy human diet should include phytonutrients such as carotenoids. Several approaches including classical breeding and transgenic plant production have been used to increase carotenoid abundance in plant tissues; challenges to these approaches include feedback controls, cell toxicity due to abnormally…

Marchantia polymorpha (a liverwort) is a living relative of the earliest terrestrial plants. As it has a simple genome and morphology and is readily transformable, it provides a good platform for synthetic biology (see https://www.openplant.org/marchantia/). Delmans et al. have designed an “engineering-oriented”…

Filmed for iBiology 2016 Talk Overview Dr. Jay Keasling discusses the promise of biological systems to create carbon-neutral products for a range of applications, including fuels, chemicals and drugs. Keasling discusses the application of these principles to the development of a microbial platform…

Our way of life depends on the chemical manufacture of thousands of products. Some of these can be produced through biomanufacturing, which may involve starting with a biological starting material, or using an enzyme or organism as catalyst. Advances in synthetic biology, metabolic engineering and genomics…