Review: The systems biology of auxin in developing embryos ($)

The transcriptional response to auxin depends in large part on the interactions between ARF transcription factors and the Aux/IAA transcription inhibitors that interact with them. The crucial role of auxin in embryo patterning is revealed by the embryo patterning defects observed in mutants of ARF and Aux/IAA proteins as well as auxin synthesis and transport mutants. Mironova et al. review recent research into the role of auxin in embryo development, focusing on mathematical and structural models of auxin signaling, and particularly how a better understanding of the interactions amongst and between ARFs and Aux/IAA proteins enhances modeling efforts. Trends Plant Sci. 10.1016/j.tplants.2016.11.010