Review: Emerging roles of long noncoding RNAs in the cytoplasmic milieu (non-coding RNA)

Review: Emerging roles of long noncoding RNAs in the cytoplasmic milieu

Note: This article focuses on work in mammalian systems but may be of interest to plant biologists. Long non-coding RNA (lncRNAs) are ³200nt RNAs and represent almost 0.2% of cellular RNA pool. Early work focused on their roles in the nucleus, but more recently it has become clear that they also function in the cytoplasm, as reviewed here by Aillaud et al. In the cytoplasm, lncRNAs interact with ribosomes and regulate mRNA translation positively and negatively. They also interact with mitochondria and have roles in cell death and signal transduction during environmental changes, and also regulate endoplasmic reticulum (ER)- dependent autophagy. Various studies have shown the recruitment of lncRNAs with mRNAs in stress granules and with proteins in forming processing bodies. The authors also highlight the involvement of lncRNAs in ubiquitination-dependent protein processing and decay. This review is a great resource on how mammalian lncRNAs affect spatiotemporal responses of cytoplasmic organelles during stress condition. (Summary by Sunita Patak @psunita980) non-coding RNA 10.3390/ncrna6040044