Intracellular distribution of manganese by NRAMP2 critical for photosynthesis and redox homeostasis

Manganese is a micronutrient essential for the function of several proteins including manganese superoxide dismutase (localized in the peroxisome and mitochondria) and the photosystem II reaction center (localized in the chloroplast). Mn is transported via NRAMP (Natural Resistance-Associated Macrophage Protein) transporters.  Through reverse genetics and functional complementation of yeast mutants, Alejandro and Cailliatte et al. explore the contribution of NRAMP2 to Mn homeostasis. They show decreased Mn accumulation in organelles of nramp2 mutants, and that the NRAMP2 protein predominately accumulates in the trans-Golgi network. The authors speculate that the protein functions at an early cross-road of the Mn distribution pathway.  (Summary by Mary Williams) Plant Cell  10.1105/tpc.17.00578