Yuanyuan Zhou, co-first author of “The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis”
Current position: University of Chinese Academy of Sciences, Doctoral candidate
Education: Chongqing Normal University, bachelor’s degree
Non-scientific Interests: travel , play badminton
I graduated from Chongqing Normal University with a bachelor’s degree in 2016. In the same year, I joined the research group of Professor Dongping Lu at the Agricultural Resources Research Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and started my postgraduate study. During this period, I focused on the plant innate immunity signaling pathway study of Arabidopsis thaliana. In this study, we found two E3 ligases ATL31/6 were up regulated after flg22 treatment and ATL31/6 can ben interacted with a negative immune regulator CPK28. ATL31/6 directly ubiquitinated CPK28, resulting in its proteasomal degradation. Thereby, CPK28 function was blocked. In addition, ATL31/6 promoted the stability of BIK1 by mediating CPK28 degradation. Related mutants and overexpressed materials further confirm the genetic relationship between ATL31/6 and CPK28., Finally we confirmed the ATL31/6-CPK28-BIK1 immune signaling pathway in plant innate immunity response.