Yuanyuan Zhou: The Plant Cell First Author

Yuanyuan Zhou, co-first author of “The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis”

Current position: University of Chinese Academy of Sciences, Doctoral candidate

Education: Chongqing Normal University, bachelor’s degree

Non-scientific Interests: travel , play badminton

Brief bio:

I graduated from Chongqing Normal University with a bachelor’s degree in 2016. In the same year, I joined the research group of Professor Dongping Lu at the Agricultural Resources Research Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and started my postgraduate study. During this period, I focused on the plant innate immunity signaling pathway study of Arabidopsis thaliana. In this study, we found two E3 ligases ATL31/6 were up regulated after flg22 treatment and ATL31/6 can ben interacted with a negative immune regulator CPK28.  ATL31/6 directly ubiquitinated CPK28, resulting in its proteasomal degradation. Thereby, CPK28 function was blocked. In addition, ATL31/6 promoted the stability of BIK1 by mediating CPK28 degradation. Related mutants and overexpressed materials further confirm the genetic relationship between ATL31/6 and CPK28., Finally we confirmed the ATL31/6-CPK28-BIK1 immune signaling pathway in plant innate immunity response.

姓名：周园园

职位：中国科学院大学，在读博士研究生

学历：重庆师范大学，学士学位

兴趣爱好：旅行，打羽毛球

个人简介：

我于2016年本科毕业于重庆师范大学。同年，进入中国科学院遗传与发育生物学研究所农业资源研究中心吕东平研究员课题组开始研究生阶段的学习。期间，我主要从事拟南芥天然免疫信号通路的研究。我们发现两个E3泛素连接酶ATL31/6受FLG22诱导上调表达，并且免疫负调控蛋白CPK28能直接与ATL31/6互作，ATL31/6通过直接泛素化CPK28，导致其蛋白质降解，进一步解除对免疫的抑制作用。此外，ATL31/6通过介导CPK28降解促进BIK1的稳定性，从而正调控拟南芥天然免疫。同时，我们获得突变体和超表达材料，通过它们的免疫表型进一步确定了ATL31/6和CPK28的遗传关系，最终确定了ATL31/6-CPK28-BIK1免疫信号通路。