In an interesting and accessible review, Peyraud et al. provide a big-picture view of how systems biology can be used to address plant-pathogen interactions. They describe the core interactions scaling from molecular to ecosystem / environment, and describe the different types of models that can be used to assess and predict the outcomes, as well as the types of data needed for model development. They also point to the many gaps in available datasets and suitable models. The incorporation of a Glossary as well as illuminating illustrations make this paper particularly well suited for teaching. Plant J.