Proteome-wide, structure-based prediction of protein-protein interactions (Plant Physiol)
Genomics and transcriptomics have brought huge advances in understanding of plant science, but proteomics is both more challenging and in some ways more relevant to understand what is happening inside of a cell. Proteins function largely through their interactions with other proteins, so it is important to be able to confidently predict protein-protein interactions. Dong et al. describe a molecular interactions viewer that builds upon demonstrated structural and interaction data to predict protein-protein interactions. The authors predict new interactions which they verify using yeast-two hybrid studies. Their predicted structure-ome is freely available through the Bio-Analytic Resource (BAR) as the Arabidopsis Interactions Viewer 2 (http://bar.utoronto.ca/interactions2/). (Summary by Mary Williams) Plant Physiol. 10.1104/pp.18.01216.