Predicting metabolism during growth by osmotic cell expansion (bioRxiv)
Growth is driven by cell expansion, which is driven by both synthesis of metabolites and osmotically-driven expansion. This latter contribution is typically overlooked in metabolic flux analysis. To remedy this, Shameer et al. have developed a model, GrOE-FBA (Growth by Osmotic Expansion- Flux Balance Analysis). By combining previously described osmotic constraints with biomass constraints, they […]