ARGONAUTE10 promotes degradation of miR165/6 through SDN1 and SDN2 exonucleases
ARGONAUTE10 (AGO10) was first identified through genetic studies in the 90s; loss-of-function mutants (zwille, pinhead) show premature differentiation of the shoot apical meristem. Although the mechanism has remained uncertain, AGO10 has been shown to suppress accumulation of miR165/6, which are key regulators of a large number of developmentally important transcription factors. Yu, Ji, and Le […]