Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 ($)
Polycomb repressive complex 2 (PRC2) stably regulates gene expression by initiating repressive histone methylation (specifically, trimethylation of histone H3 at Lys27, H3K27me3). Xiao et al. investigated how PRC2 targets the genes it silences. They identified several Polycomb response elements (PREs) that are binding sites for transcription factors which interact with PRC2. When selected PREs were […]