Low-gluten, non-transgenic wheat engineered with CRISPR/Cas9
Celiac disease is a debilitating autoimmune disease in which antigens in plant gliadins (one type of gluten protein) stimulate production of antibodies that inflame the lining of the small intestine. In wheat, α-gliadin (the main cause of the sensitivity) is encoded by more than 100 genes, thwarting their elimination through traditional breeding methods. Sánchez-León et […]