Heat shock proteins support refolding and shredding of misfolded proteins
Author: Masanori Izumi Affiliation: RIKEN Center for Sustainable Resource Science, Wako 351-0198, Japan Newly synthesized proteins must be folded to form their proper 3D structures. Stresses perturb protein folding, thereby leading to the hyperaccumulation of misfolded or aggregated proteins. Such disrupted proteostasis causes proteotoxic stress that impairs cellular functions, and organisms must refold or remove […]