Entries by Caroline Dowling

Genome-phenome wide association in maize and Arabidopsis identifies a common molecular and evolutionary signature (Mol. Plant)

Genome-wide association studies (GWAS) are widely used to link natural genetic variation to trait variation, with a single or a select few correlated traits assessed. High-throughput phenotyping allows the scoring of hundreds of individuals for various traits at several time points. An undeniable consequence of quantitative genetics research is the creation of large, complex datasets […]

Gene balance predicts transcriptional responses immediately following ploidy change in Arabidopsis thaliana (Plant Cell)

Throughout evolutionary time polyploidization events have occurred frequently, increasing the gene copy number (gene dosage) of multiple angiosperms. The gene balance hypothesis proposes that there is selection on gene copy number to maintain the stoichiometric balance between dosage-sensitive genes that are involved in multimeric complexes (e.g., transcription factors). However, if a whole-genome duplication occurs the […]

Roles for CHROMATIN REMODELING 4 in Arabidopsis floral transition (Plant Cell)

The time at which flowers appear is critical for plant reproductive success. As such, the vegetative to reproductive growth transition is governed by several cues: environmental (photoperiod, temperature) and endogenous (gibberellins, age). Here, Sang et al. used an elegant forward-genetics approach to identify uncharacterized regulators of the Arabidopsis endogenous flowering time pathways. A quintuple mutant […]

Perspective: Multiscale computational models for crop improvement (Plant J)

Throughout the plant science community, the use of computational or in silico analyses which precede traditional studies are gaining traction to identify research opportunities. Multiscale computational models are those which assimilate data from all biological system levels from gene to ecosystem. Benes et al. advocate for the use of such multiscale models to advise crop […]

Opinion: We aren’t good at picking candidate genes, and it’s slowing us down (COPB)

Recent advances have facilitated the generation of huge phenotypic datasets from plant populations. However, the means to inexpensively organise such datasets to unequivocally determine causal genes has evaded researchers. Here, Baxter discusses how human bias when selecting candidate genes is compromising research efficiency. When utilising breeding populations for association mapping, a genomic region correlated to […]

Review: Pathways to sex determination in plants: How many roads lead to Rome? (COPB)

Although most angiosperms produce both male and female gametes, in some species an individual is either male or female, a property known as dioecy (literally, two houses). Dioecy exists in ~6% of angiosperms and is hypothesized to have evolved several times independently. While much research has been conducted to comprehend the molecular basis of sex […]