Yue Niu: The Plant Cell First Author

Yue Niu, co-first author of “The phospholipid flippase ALA3 regulates pollen tube growth and guidance in Arabidopsis”

Current Position: Associate professor in School of Life Sciences, Lanzhou University.

Education: Ph.D. in School of Life Sciences with Prof. Guochang Zheng (Academician of CAS) at Lanzhou University.

Non-scientific Interests: Reading and Travelling

Brief bio：I did my Ph.D. at Prof. Guochang Zheng’s lab in Lanzhou University with the screening of mutant and related genes involved in plant responses to adverse environment. After the doctoral studies, I joined Prof. Yun Xiang’s Lab at Lanzhou University, in which I started my research journey on exploring the molecular and physiological functions of Arabidopsis phospholipid flippases. Type IV P-type ATPases (P₄-ATPases) function as flippases which were required for the lipid asymmetry via flip-flopping specific phospholipids across membrane leaflets. The protein family were known to be found only in eukaryotic cells. Arabidopsis P₄-ATPases termed Aminophospholipid ATPases (ALAs) were composed of 12 members which had been identified to have manifold capabilities. In our work, we discovered that ALA3 influence the precise localization of PRKs by regulating the distribution of anionic phospholipids during pollen tube growth and guidance. Our findings revealed a novel role for Arabidopsis P₄-ATPase in regulating plant reproduction.

发表论文：拟南芥磷脂翻转酶ALA3调控花粉管生长和导向

姓名：牛月

目前职位：副教授，兰州大学生命科学学院

教育经历：兰州大学，理学博士，导师：郑国锠院士

兴趣爱好：阅读，旅游

 个人简介：

在兰州大学郑国锠院士实验室攻读博士学位期间，我主要从事逆境胁迫应答相关突变体和基因筛选工作。博士毕业后，我加入兰州大学向云教授的研究团队，开始参与拟南芥磷脂翻转酶的分子生物学和生理学功能的研究。P₄型ATP酶是一类磷脂翻转酶，主要通过在生物膜两侧翻转特定的磷脂从而构建膜磷脂的不对称性。这个蛋白家族目前发现只存在于真核细胞中。拟南芥P₄-ATP酶又称为氨基磷脂ATP酶(ALAs)，由12个家族成员构成，该家族成员目前已被证实具有多重的生理功能。在本研究中，我们发现此蛋白家族成员ALA3通过影响负电荷磷脂介导的PRKs的精确定位调控花粉管生长和导向。我们的研究发现了拟南芥P₄-ATP酶在调控植物生殖方面的一个新机制。