Yuan Guo: The Plant Cell First Author

Yuan Guo, co-first author of “CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 is an RNA-binding protein controlling plant immunity via RNA processing complex”

Current Position: Engineer in Sanyou Biopharmaceuticals Co., Ltd, China

 Education: M.S. in Botany, Shanghai Normal University, China; B.S. in Chemical Biology, Hengyang Normal University, China

 Non-scientific Interests:  Travelling, Shopping

 Brief bio: Since joined Prof. Shui Wang’s lab in 2018, I have been using Arabidopsis cpr5 mutant as research materials to explore the mystery of plant disease resistance. Plant immune system is different from animal immune system, so we explore the feature of plant immunity. The plant-specific nucleoporin CPR5 negatively regulates plant effector-triggered immunity (ETI) and programmed cell death (PCD) which has always been of interested to our lab. To understand the underlying mechanism of the CPR5-mediating plant immunity, we have explored transcriptional regulation, protein domain structure and protein stability. We found that many genes were up-regulated in cpr5 mutant, mostly enriched in plant immunity. With the joint efforts of my lab mates, we found that CPR5 is an atypical RNA-binding protein with a conservative domain. Through a series of studies, we found that CPR5 protein regulates plant immunity through RNA processing complex. The new findings will open a new world for the lab to further explore plant immunity.

姓名：郭缘

 目前职位：三优生物医药（上海）有限公司，工程师

教育背景：上海师范大学，植物学，硕士学位；衡阳师范学院，化学生物学，学士学位

 兴趣爱好：旅行，购物

 个人简介：从2018年加入王水老师课题组以来，我一直以拟南芥cpr5突变体为研究材料探寻植物抗病的奥秘。植物免疫系统和动物免疫系统具有差异，因此我们探索植物免疫的特殊性。植物特异的核孔蛋白CPR5负调控植物效应子触发免疫和程序性细胞死亡，其信号通路一直是我们课题组感兴趣的地方。在研究CPR5蛋白调控植物免疫机制的方面，我们探索了转录调控，蛋白不同的结构域以及蛋白稳定性。我们发现该突变体背景下大量的基因被激活，其中富集免疫调控相关的基因。经过课题组成员的共同努力，我们发现CPR5是一非典型的RNA结合蛋白，具有十分保守的结构域。通过一系列的研究表明，CPR5蛋白是通过RNA加工复合体调控植物免疫。新的研究发现为课题组打开了一个新的探索植物免疫的世界。