Xiaotong Liu: The Plant Cell First Author

Xiaotong Liu, co-first author of “The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis”

Current Position: Assistant researcher at the Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Education: Ph.D. Crop Science from Chinese Academy of Agriculture Science

Non-scientific Interests: Listening Rock Music, Traveling and Playing with my cat

Brief bio: I joined Prof. Dongping Lu’s lab in Chinese Academy of Sciences when I get my Ph.D. degree from Chinese Academy of Agriculture Science. My research focus on Plant Biotic Interactions. I keep my research interest in understanding the mechanism of plant innate immunity. I find a negative immune regulator CPK28 was tightly regulated by two E3 ligases ATL31 and ATL6. ATL31/6 directly ubiquitinate CPK28, resulting in its proteasomal degradation. Furthermore, ATL31/6 promote the stability of BIK1 by mediating CPK28 degradation. Consequently, ATL31/6 positively regulate BIK1-mediated immunity. Our findings reveal a mechanism for attenuating CPK28 function to maintain BIK1 homeostasis and to enhance immune responses. I hope the finding will contribute to scientific development in this field.

姓名：刘晓彤

职位：中国科学院遗传与发育生物学研究所农业资源研究中心，助理研究员

学历：中国农业科学院，博士研究生

兴趣爱好：摇滚乐，旅行，猫

个人简介：

我博士毕业于中国农业科学院，后加入中国科学院吕东平研究员课题组开展植物-微生物互作方向的研究。我主要关注植物天然免疫途径的机制研究。我发现在植物天然免疫途径中起负调控作用的关键因子CPK28能够被两个E3泛素连接酶ATL31和ATL6介导泛素化，进而被26S蛋白酶体降解。另外，ATL31和ATL6能够通过调控CPK28间接促进胞质类受体激酶BIK1积累。我们的发现揭示了一个新的通过调控BIK1丰度从而调控植物免疫强度的途径。我希望这一发现将有助于这一领域的科学发展。