Chloroplast proteostasis prevents aggregation of Huntington’s disease-causing human polyQ protein
Plant Science Research WeeklyCertain human neurodegenerative disorders are caused by aggregation of disordered proteins. In particular, Huntington’s disease is caused by aggregation of a protein called huntingtin, which contains long stretches of glutamine (Q). Llama et al. observed that proteins with long stretches of glutamine…
Chloroplast protein import determines plant proteostasis and retrograde signaling (bioRxiv)
Plant Science Research WeeklyThe neurological condition Huntington’s disease is caused by mutated versions of the Huntingtin gene that encode expanded stretches of polyglutamine repeats, resulting in protein aggregation. However, despite the widespread presence of polyglutamine repeat regions in plant proteomes, similar pathologies…