Tag: metabolic engineering

Withania somnifera (ashwagandha) is popularly known for its most prominent bioactive compound called withanolide. This natural product has enormous medicinal potential and has traditionally been used in the Indian Ayurvedic system for more than 3000 years to treat various illnesses. However, the industrial…

For more than two centuries, quinine from Cinchona bark has stood as one of the best-known plant-derived medicines for malaria treatment, but the enzymes that build its distinctive scaffold were unknown. Lombe et al. have now resolved the core logic of cinchona alkaloid biosynthesis in Cinchona pubescens,…

Photosynthesis is nature’s most powerful carbon capture system, fueling life on Earth and inspiring new strategies for sustainable agriculture. In plants, The Calvin–Benson–Bassham cycle generates C3 carbohydrates but is inefficient at producing the two-carbon acetyl–coenzyme A (CoA), which is…

Photosynthesis is nature’s most powerful carbon capture system, fueling life on Earth and inspiring new strategies for sustainable agriculture. In plants, The Calvin–Benson–Bassham cycle generates C3 carbohydrates but is inefficient at producing the two-carbon acetyl–coenzyme A (CoA), which is…

Nicotiana benthamiana is widely used to reconstruct complex, multi-step metabolic pathways for research or industrial purposes. This is enabled by rapid and high-level protein expression after agroinfiltration. Within cells, as well as membrane-bound organelles, nonmembrane-bound biomolecular condensates…

Paclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.)  and a potent stabilizer of microtubules that is effective in treatment of cancers. However, it has proven difficult to elucidate its biosynthetic pathway, and commercial production still relies on extracting an…

Rice feeds nearly half of the world population. Rice grains are rich in starch but low in micronutrients and bioactive compounds such as flavonoids. By contrast, tea leaves are rich in antioxidants such as catechins but low in calories. Zhu and colleagues combine the advantages of rice and tea by producing…