Shuai Wang, co-first author of “Phosphorylation and ubiquitination of OsWRKY31 are integral to OsMKK10-2-mediated defense responses in rice”
Current Position: Ph.D. at College of Plant Protection, China Agricultural University，China
Education: M.A. at College of plant Science and Technology, Beijing University of Agricultural，China
Non-scientific Interests: Sports and Reading
Brief bio: The undergraduate and master level preliminary contact with molecular biology experiments, which gave me a strong interest in the molecular mechanism of plant disease resistance regulation. In 2017, I had the honor to be a doctoral student of Professor Guo Zejian, and began to engage in the research of rice WRKY transcription factors in regulating disease resistance. Our group identified OsWRKY31, a positive regulator of resistance to M. oryzae and found that OsWRKY31, OsMPK3 and OsMKK10-2 interact in the nucleus and function in a complex. Activation of OsMKK10-2 is able to increase the accumulation of jasmonic acid and salicylic acid, thereby enhancing M. oryzae resistance and inhibiting plant growth by reducing the level of indole-3-acetic acid. Whereas, as a downstream transcription factor of OsMKK10-2, knockout of OsWRKY31 impairs OsMKK10-2-mediated defense responses. Phosphorylated form of OsWRKY31 not only enhanced protein stability but also had high DNA binding activity and enhanced resistance to M. oryzae. Moreover, OsWRKY31 also undergo ubiquitination through the E3 ubiquitin ligase OsREIW1 to regulate the self- stability. Currently, I am studying for a PhD and my current research is to further explore the interactive response of OsWRKY31 in phosphorylation and ubiquitination in disease resistance, in order to gain a deeper understanding of the precise regulation of defense and growth balance.