Recognizing Plant Cell authors: Yuan Xie
Yuan Xie, co-first author of Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle
Current Position: Postdoctoral Associate in Department of Biophysics, Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Research Experience: Postdoctoral Associate in Weill Cornell Medicine College, New York, NY, USA, Supervisor: Prof. Crina Nimigean
Education: Ph.D. in National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Supervisor: Prof. Wenrui Chang and Prof. Mei Li
Non-scientific interests: music, movies, traveling, and reading
Brief bio: During my master’s and Ph.D. degree, I developed a strong interest in biophysics. Through x-ray crystallography and cryo-electron microscopy, high-resolution structures of the proteins can be obtained. By systematically analyzing the structure of proteins, the mechanism and the regulation mode of the target protein could be revealed. My research focused on photosynthesis and related proteins, including photosynthetic membrane proteins and enzymes involved in photosynthesis. After that, my post-doc work mainly includes the structure and regulatory mechanism of ion channels and transporters. Human ion channels and transporters are ubiquitous membrane proteins, which are vital to cellular processes such as cell membrane excitability, propagation of nervous stimuli and molecule transport. Defects in these proteins can alter their function and regulation, which can lead to an imbalance in the cell homeostasis and even human disease. A detailed study of these proteins can provide us with more information to reduce the occurrence and development of diseases.
姓名：解媛
职位：学科博士后，浙江大学医学院附属邵逸夫医院病理生理学生物物理学系，中国杭州，郭江涛研究员实验室
科研经历：博士后，威尔·康奈尔大学医学院，美国纽约，Crina Nimigean教授实验室
学历：博士，中国科学院生物物理研究所，中国北京，常文瑞研究员和李梅研究员实验室
非科学兴趣：音乐，电影，旅行，阅读
简介：在硕博期间，我对生物物理学产生了浓厚的兴趣，通过x-射线晶体学和冷冻电镜的方法，能够获得蛋白质的三维结构，通过系统的分析蛋白质的结构，我们能够得知蛋白质分子是如何发挥作用以及如何受到不同方式的调节。在硕博期间，我的研究主要集中在光合系统的相关蛋白上，包括光合膜蛋白以及参与光合作用的酶类。而我博士后期间的工作，主要包括离子通道和转运蛋白的结构和调控机制。人类离子通道和转运蛋白是普遍存在的膜蛋白，对细胞的生命活动如细胞膜兴奋性，神经刺激的传播和分子转运等细胞活动过程至关重要。这些蛋白质的缺陷会改变其功能和调节方式，从而导致人体生命活动稳态的失衡甚至是导致疾病。对这些蛋白质的详细研究可以为我们提供更多的信息，以减少疾病的发生和发展。
