Sabine Brumm, first author of Coordinated activation of ARF1 GTPases by ARF-GEF GNOM dimers is essential for vesicle trafficking in Arabidopsis
Current Position: Post-Doc, Sainsbury Laboratory University of Cambridge, Cambridge, UK
Education: Ph.D. from University of Tübingen, ZMBP, developmental genetics department under the supervision of Prof. Dr. Gerd Jürgens; MSc and BSc from the University of Tübingen
Non-scientific Interests: traveling, sports, literature
Brief Bio: As part of a cooperation with the Centre for Plant Molecular Biology (ZMBP) in Tubingen, I spent half a year in the laboratory of Marcelo Desimone (National University of Cordoba, Argentina) to complete my MSc in Plant Molecular Biology. In Cordoba, I studied the subcellular localization of a putative hormone transporter in Arabidopsis thaliana. Afterwards, I re-joined the ZMBP as a PhD student in the group of Gerd Juergens who is interested in the molecular mechanisms underlying the directed transport of proteins in plant cells. My two main projects focused on the analysis of how small ARF-GTPases and their respective ARF-GEFs contribute to the specificity of vesicle formation in Arabidopsis thaliana. I was able to show that the dimerization of ARF-GEFs plays an important role in the coordinated activation of the small GTPase ARF1, which is one of the major regulators of vesicle budding processes in eukaryotic cells. I am now working as a post-doc in the group of Sebastian Schornack at the Sainsbury laboratory in Cambridge. In the future I would like to contribute to a better understanding of the regulatory trafficking mechanism underlying plant-microbe interactions by combining scientific approaches from both research fields.