Mechanisms of RALF peptide perception by a heterotypic receptor complex (Nature) ($)

/in /by

RALFs (Rapid Alkalinization Factors, based on historical observations that they induce alkalization of the extracellular space) are signaling peptides with diverse roles. RALFs have previously been shown to bind to the extracellular domain of (among others) FERONIA (FER), a member of the Catharanthus roseus RLK1-like (CrRLK1L) family. LORELIE-Like GPI-membrane anchored protein (LLG) has been shown to operate in the FER signaling pathway. Now, Xiao et al. have found that RALF23 binds to a complex formed by FER and LLG. They also identified an N-terminal “YISY” sequence that is conserved in other RALFs and that is important for this interaction. Their data also suggest that the RALF+FER can interact with other LLGs, which could explain the diverse processes that RALFs and FER are involved in. (Summary by Mary Williams) Nature 10.1038/s41586-019-1409-7

You might also like
Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin receptor assemblies ($) (BioRxiv)
Review. Milestones in understanding phosphorus uptake, transport, sensing, use, and signaling
Cryo-EM structure of OSCA1.2 sheds light on the mechanical basis of membrane hyperosmolality gating (PNAS) ($)
miRNA-mediated lateral inhibition controls rhizoid cell patterning in Marchantia polymorpha (Curr. Biol.)
Identification of calmodulin-dependent NAD+ kinase that sustains the elicitor-induced oxidative burst (Plant Phys)
Natural variation identifies a Pxy gene controlling vascular organization and formation of nodules and lateral roots in Lotus japonicus (New Phytol.)
Ferns unleashed: Novel insecticidal proteins IPD113 challenge Bt resistance
The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway (eLIFE)