Lei Deng, co-first author of “Tomato MED25 Regulates Fruit Ripening by Interacting with EIN3-like Transcription Factors”
Associate Professor, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Ph.D. in Chongqing University (CQU)
Non-scientific Interests: Running, cooking and music
Brief bio: I received my Ph.D degree at the Chongqing University and then joined Prof. Chuanyou Li’s lab at the Institute of Genetics and Developmental Biology, Chinese Academy of Science to start my postdoctoral study. I have been using tomato as a model to study plant immunity and fruit quality formation.
In this project, we investigated the mechanistic function of MED25, a subunit of the plant Mediator transcriptional coactivator complex, in regulating tomato fruit ripening. We found that MED25 physically interacts with EIN3-like (EIL) transcription factors to orchestrate ethylene-mediated transcriptional reprogramming during fruit ripening. We demonstrated that MED25 forms a transcriptional module with EILs to regulate the expression of ripening-related regulatory as well as structural genes through promoter binding. We also demonstrated that the EIL–MED25 module forms both positive and negative feedback loops with its downstream regulators to maintain ethylene homeostasis during ripening.