Jieming Jiang, first author of “A diRNA–protein scaffold module mediates SMC5/6 recruitment in plant DNA repair”
Current Position: Associate Research Fellow
Education: South China Normal University, Doctor
Non-scientific Interests: Keep pets, Travel
Brief bio: I joined the research team of professor Yang in 2012, and engaged in the research on the molecular regulation mechanism during plant DNA repair. The structure maintenance complex SMC5/6 is highly conserved in eukaryotes, and we have shown that it was dissociated from its original chromosomes and further recruited to the DNA double-strand break sites by co-activator ADA2b, thus participating in subsequent repair. The results were published in PNAS and Plant Physiology, respectively. Here, we showed that CDC5, the subunit of MAC complex, regulated the localization of ADA2b and further be attracted to DNA double-strand break sites through the medication of IDN2-diRNA/AGO2 complex. Therefore, we finally proved that the localization of SMC5/6 complex at DNA double-strand break sites was regulated by the diRNA/AGO2 complex. However, there are still many unsolved questions in this field, and I hope my research can provide useful help for agricultural or cancer research.