Entries by Jesus Leon

RHO GTPase of plants regulates polarized cell growth and cell division orientation during morphogenesis

Precise spatial control of cell division and cell growth is necessary to produce the specific cellular organizations demanded by the complex tissues and organs of morphologically complex organisms One of many factors that guide cell division/growth is cell polarity, of which RHO GTPase-type proteins have emerged as conserved eukaryotic regulators. RHO of Plants (ROP) form […]

Developmental functions of Marchantia ROP

Precise control of cell division is an important requirement for proper development in multicellular organisms. Rho-like GTPases from Plants (ROPs) are key conserved regulators of cell polarity and morphogenesis, however, it is unknown if ROP signaling pathways regulate cell division patterning and meristem formation during embryogenesis and organogenesis. Additionally, the high degree of genetic redundancy […]

A conserved superlocus regulates above- and belowground root initiation (Science)

The vascular plant body composed of root and shoot is specified during embryogenesis, but most flowering plants can also develop additional root systems post-embryonically: lateral roots, as a response to wounding, or shoot-borne roots (“adventitious” roots, literally meaning “in the wrong place”). The initiation mechanism of these roots as well as their parent tissue and […]

Review: Cycling in a crowd: coordination of plant cell division, growth and cell fate (Plant Cell)

Unlike animal cells, plant cells cannot migrate due to the presence of interconnected rigid cell walls, thus plant development relies on a continuous supply of new cells, (fueled by the cell cycle) to form new organs throughout their life. This excellent review by Sablowski and Gutierrez focuses on the intricate regulatory networks and cell cycle […]

Plant PIEZO homologs modulate vacuole morphology during tip growth (Science)

The ability to perceive and respond to mechanical stimuli and forces, such as gravity or touch, is an extremely well conserved property that is key for proper cellular function. This ability is fueled by mechanosensitive ion channels activated by mechanical disturbances in the membrane, which leads to flow of ions down their electrochemical gradients. In […]

Deceleration of cell cycle underpins a switch from proliferative-to-terminal division in plant stomatal lineage (bioRxiv)

Precise cell cycle control is essential for the differentiation of specialized cell types. Stomata, essential pores for gas exchange located in the epidermis, are generated via proliferative asymmetric cell division (ACD) of a transient stem cell called a meristemoid, which will give rise to a guard mother cell that will undergo a single symmetric cell […]

A spatiotemporal molecular switch governs plant asymmetric cell division (Nature Plants)

In multicellular organisms, stem cells produce various cell types through asymmetric cell division (ACD), which is achieved is through polarization of cell-fate determinant proteins in the ACD progenitor cells. In Arabidopsis stomatal development, an ACD progenitor cell, the meristemoid mother cell (MMC), produces daughter cells with different cell-fates: a meristemoid and a stomatal lineage ground […]

LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate (Nature Comms)

Master transcription factors (TFs) can activate specific genetic programs to reprogram cellular fate in the context of open chromatin. A special class of these proteins known as pioneer TFs are defined by their ability to trigger cell fate reprogramming by binding their cognate cis motifs in a nucleosome context both in vitro and in vivo, […]

Molecular mechanism of cytokinin-activated cell division in Arabidopsis (Science)

Proper organogenesis depends on the precise control of cell proliferation and differentiation. Cytokinin and auxin have emerged as key regulators of both these processes, where cytokinin promotes proliferation and synergistically with auxin fine-tunes the proliferation and differentiation rate. Years of research and evidence have implicated cytokinin as a central regulator of stem cell proliferation in […]