Yang Li, first author of “The RNA helicase UAP56 and the E3 ubiquitin ligase COP1 coordinately regulate alternative splicing to repress photomorphogenesis in Arabidopsis”
Current Position: Ph.D. (job hunting), Institute of Botany, Chinese Academy of Sciences
Education: Ph.D. from Institute of Botany, Chinese Academy of Sciences
Non-scientific Interests: Reading, Swimming
I have pursued my Ph.D. under the supervision of Prof. Rongcheng Lin at the Institute of Botany, Chinese Academy of Sciences. My Ph.D. thesis investigated the underlying mechanisms of light precisely regulate seed dormancy and photomorphogenesis in Arabidopsis. My research identified RNA helicase UAP56 as a negative regulator of photomorphogenesis in Arabidopsis. UAP56 interacts with E3 ligase COP1 in vitro and in plant cells. RNA sequencing analyses revealed that UAP56 and COP1 coordinately regulate the expression levels of many genes as well as the splicing of many common pre-mRNAs. RNA immunoprecipitation assays demonstrated that UAP56 and COP1 bind to common snRNAs and target mRNAs. This study identifies a new role of UAP56 in regulating light-mediated seedling growth as well as a new mechanism for UAP56 and COP1 in modulating pre-mRNA alternative splicing in plants, enriching the regulatory network of light signals.