Feroza K. Choudhury, first author of Local and systemic metabolic responses during light-induced rapid systemic signaling
Current position: Postdoctoral fellow at Washington University in St. Louis, Missouri, USA
Education: PhD in Biochemistry and Molecular Biology, University of North Texas, Texas, USA
Non-scientific interests: Travelling
Brief Bio: Driven by my fascination towards the systems view of a biological problem, during my PhD I got extensive training in doing high throughput metabolic profiling and analyzing it in the context of metabolic networks as an elementary technique in systems biology for generating hypotheses, followed by designing experiments using mutants and imaging for biological validation. In this approach, I have determined rapid response of the metabolic pathways to light stress in Arabidopsis, based on that predicted the role of nitric oxide in inducing the metabolic reprogramming and validated it with imaging and metabolic analysis. Next, I have studied metabolic changes associated with ROS mediated rapid systemic signaling, which led to identify the role of cytosolic isocitrate dehydrogenase in producing NADPH to feed RBOHD to support the propagation of ROS wave. Currently, I am working as a postdoctoral fellow in Patti lab at Washington University to study oxidative stress induced alteration of metabolism in cancer, starting from metabolic interaction within different organelles in a cell to communication of a cell to its microenvironment by using advanced metabolomics technologies.