Lu-Shen Li, first author of Calmodulin-Binding Protein 60b is a central transcriptional activator of immunity
Current Position: PhD candidate in Prof. Yan Zhang’s lab at Shandong Agricultural University, Shandong, China
Education: BS in College of Life Sciences, Shandong Agricultural University, Shandong, China; doctoral candidate at Shandong Agricultural University
Non-scientific Interests: listening to classic music, reading
Brief bio: In September 2015, I was lucky to join the research group of Professor Yan Zhang, Shandong Agricultural University to start my research career. My doctoral research focused on the functional characterization of calmodulin-binding protein 60b in immunity. We determined that CBP60b mediates the basal expression of immune genes including CBP60g and SARD1 so that plants maintain basal immunity during plant development. Upon pathogen invasion, CBP60b are induced and activated, and positively regulates immunity by directly and indirectly activating the expression of immune genes. Therefore, we proved that CBP60b is a central transcriptional activator of immunity. Because CBP60b and its signaling pathways play such an important role in immunity, specific NLR proteins are used to monitor CBP60b and/or CBP60 downstream components to avoid immune deficiency caused by pathogen effectors. Functional loss of CBP60b mimics the effect of the effectors attack, so that the cognate NLR triggered the ETI response constitutively, which interfered with the normal development process of plants and thus led to the developmental defects.