Recognizing Plant Cell authors: Yen-Ling Lin

Yen-Ling Lin, first author of SUMO Protease SMT7 Modulates Ribosomal Protein L30 and Regulates Cell-size Checkpoint Function

Current Position: Ph.D. Candidate in Ph.D. Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taiwan

Education: BS in Department of Life Science, National Chung Hsing University and MS in Institute of Molecular Medicine, National Cheng Kung University, Taiwan

Non-scientific Interests: music, movie, swimming, playing with cat

Brief bio: My interest in cancer biology started when I was in the college. I chose to study neuroblastoma during my Master training. Trained as a cancer biologist, I came to realize that a simple system would be amenable to dissect complex molecular network. I was drawn into a unicellular microalga Chlamydomonas system after joining Dr. Su-Chiung Fang’s lab as a PhD student and quickly appreciated its simplicity on size-mediated cell cycle control study. Chlamydomonas has a powerful haploid genetics and a unique multiple-fission mitotic cycle, allowing uncoupling of growth and division, that make it perfect to dissect genetic pathway of cell-size control mechanism. I am very excited that I identified a new regulatory module downstream of the Retinoblastoma pathway in Chlamydomonas. Our novel finding may potentially impact the general understanding of the cell size checkpoint function.

姓名：林彥伶

職位：博士生，就讀台灣國立中興大學與中央研究院共同設置之微生物與基因體學博士學位學程

學歷：台灣國立中興大學生命科學系學士，國立成功大學分子醫學研究所碩士

非科學興趣：音樂，電影，游泳，跟貓玩

簡介：我在大學時期對癌症生物學，特別是對於癌細胞如何逃脫正常細胞精密的細胞週期訊息調控很有興趣。碩士期間利用神經母細胞瘤細胞株研究促進癌細胞在逆境生長的分子機制。在此過程我強烈意識到一個簡化的系統對研究複雜的分子調控機制很有幫助。完成碩士研究後加入方素瓊博士的實驗室進行博士的訓練，並開始以藻類系統做研究。當時我很驚訝為什麼綠色微藻可以用來研究細胞大小的控制。而且好奇為什麼會使用衣藻？衣藻居然有與人類同源的腫瘤抑制基因！後來了解，衣藻具有單倍體遺傳系統和獨特的多重細胞分裂，是研究細胞大小調控機制的絕佳模式生物。透過研究我們發現衣藻RB腫瘤抑制基因途徑下游調控細胞大小的新機制，這使我對細胞大小調控越來越有興趣。我們的發現可以幫助大家對細胞大小調控的機制更加了解。