Li Yuan: The Plant Cell First Author

Li Yuan, co-first author of BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes

Current Position: Postdoc at Henan University, China

Education: Ph.D. in Cell Biology, Hebei Normal University

Non-scientific Interests: playing badminton

Brief bio:

I started the research of Chronobiology under the supervision of Prof. Xiaodong Xu since 2012, and received Ph.D. in cell biology from Hebei Normal University. I continued my research of circadian clock as a postdoctoral member of Professor Qiguang Xie’s laboratory at Henan University. We conducted study on the molecular mechanism of circadian clock in Arabidopsis and soybean. We found that the mutants of BBX19 showed a short-period phenotype, and the increased expression of BBX18 and BBX19 lengthened the circadian period. Moreover, we found that BBX18/19 dynamically form homodimers and heterodimers, and BBX18/19 interact with PRR9/7/5 sequentially from dawn to evening. Our results shown that the BBX19-PRRs complexes suppressed the morning-phased CCA1 and RVE8 expression via binding to their promoter regions.

姓名：袁力

目前职位：博士后（河南大学）

教育背景：理学博士（河北师范大学）

兴趣爱好：羽毛球

科研经历简介：

从2012年开始，我在徐小冬教授的指导下开始了时间生物学的研究工作；目前为河南大学谢启光教授的研究团队博士后成员；研究内容是拟南芥及大豆生物钟的调控机制。我们发现BBX19的T-DNA插入缺失突变体表现出短周期的近日节律表型，BBX18和BBX19表达量增多则会引起长周期表型。通过蛋白-蛋白互作分析，发现BBX18与BBX19可动态形成同源和异源二聚体，BBX18/19与PRR9/7/5从清晨至傍晚时序性动态互作。我们的研究揭示出BBX-PRRs复合体通过结合CCA1和RVE8等清晨基因启动子区抑制其表达。