Li Qu: Plant Physiology First Author

Li Qu, first author of “Plant casein kinases phosphorylate and destabilize a cyclin-dependent kinase inhibitor to promote cell division”

Current Position: Postdoc, School of Agriculture and Biology, Shanghai Jiao Tong University, China.

Education: Bachelor, School of Plant Protection, Shandong Agricultural University, Taian, China.

Ph.D, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.

Non-scientific Interests: Cooking and Travelling.


Brief bio:

Li Qu joined CAS Center for Excellence in Molecular Plant Sciences in 2013 after finishing her bachelor’ study in Shandong Agricultural University and further studied for doctoral degree under the supervision of Prof. Hong-Wei Xue. Her research focused on the function and mechanism of Casein kinase1 in regulating plant growth and development through post-translational modification, i.e. protein phosphorylation, by using model plant Arabidopsis thaliana. Cell cycle is one of the most fundamentally conserved biological processes of plants and mammals. Casein kinase1s (CK1s) are critical for cell proliferation in mammalian cells, while how CK1s coordinate cell division in plants remains unknown. By the system genetic and biochemical studies, she finally revealed that plant CK1, Arabidopsis EL1-like (AEL), regulates cell cycle by modulating the stability and inhibitory effects of Kip-Related Protein6 (KRP6) through phosphorylation. This work demonstrates the crucial roles of AELs in regulating cell division through modulating cell cycle rates and provides insights into the plant cell cycle regulation through CK1s-mediated posttranslational modification.






兴趣爱好: 烹饪和旅游。


渠莉于2013年本科毕业于山东农业大学,随即进入中国科学院分子植物科学卓越创新中心硕博连读,师从薛红卫研究员。其博士期间主要从事拟南芥酪蛋白激酶Casein kinase1s (CK1s)调控植物生长发育的功能和机制研究。蛋白磷酸化是一类重要的蛋白翻译后修饰,在真核生物的许多生物学过程中发挥重要的调节作用。细胞分裂是动植物保守的基础生物学过程之一,CK1s在动物中已被报道在细胞增殖方面发挥重要调控作用,但其在植物中是否参与细胞分裂的调控并不清楚。借助细胞生物学、生物化学和遗传学等手段,她系统研究了植物特有的一类CK1, Arabidopsis EL1-like (AELs),证明AELs磷酸化细胞周期的关键负调控因子Kip-Related Protein 6 (KRP6)并促进其降解从而实现对植物细胞分裂的调控。这些结果揭示了AELs介导的磷酸化调控细胞分裂的关键作用,为探究CK1介导的植物细胞周期调控提供了新思路。