HDAC1/2 mediates the chloroplast unfolded protein response through histone H4 deacetylation in Chlamydomonas
Abstract Disruption of chloroplast proteostasis activates retrograde signaling that reprograms nuclear gene expression. However, how these signals are integrated with chromatin-based transcriptional regulation remains poorly understood. Here, using a genetic suppressor screen of a conditional ClpP1-depletion mutant, we identified a histone deacetylase HDAC1/2 as a regulator of chloroplast stress…