Dongbei Guo: The Plant Cell First Author

Dongbei Guo, co-first author of “CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 is an RNA-binding protein controlling plant immunity via RNA processing complex”

Current Position: M.S. candidate, College of Life Sciences, Shanghai Normal University, China

Education: B.S. in Bioengineering, Xihua University, China

Non-scientific Interests: playing badminton, swimming

Brief bio: In high school, the scientific knowledge in biology books attracted me and I therefore developed a great interest in microorganisms. During my undergraduate study, I majored in bioengineering and learned molecular biology. In 2019, I joined Prof. Shui Wang’s lab as a master student in botany. For more than two years, I have conducted research on plant immunity with the model plant Arabidopsis. I have learned that it has long been an ongoing arms race between plants and microorganisms ever since ancient times. Our lab is mainly focused on plant effector triggered immunity (ETI) mediated by CPR5. Previous studies have found that CPR5 is localized in nuclear membrane. In this study, we further dissected the CPR5 signaling pathway and found that CPR5 is localized in nuclear speckle and links RNA processing with plant immunity. Although plant ETI has been intensively studied, how plants integrate the signaling pathways in response to microorganism infection remains an appealing issue.

姓名：郭东北

 目前职位：上海师范大学生命科学学院，植物学，硕士在读

 教育背景：西华大学，生物工程，学士学位

 兴趣爱好：羽毛球，游泳

 个人简介：高中时期，生物书上的科学知识吸引了我，我对微生物产生了极大的兴趣，本科期间在生物工程专业深入学习了分子生物学相关知识。2019年我加入了王水教授实验室，攻读植物学硕士学位，两年多来，我利用模式植物拟南芥进行植物免疫的科学研究，了解到从古至今植物和微生物之间一直进行着一场免疫—侵害的军备竞赛。我们主要研究CPR5介导的效应子触发免疫（ETI）信号通路，之前的研究发现CPR5定位在核膜上。我们这次进一步剖析了CPR5信号途径，发现CPR5定位在核斑点上，参与RNA加工来调控植物免疫。关于植物ETI研究已经许多，如何把各个通路联系起来响应病原微生物的侵染仍然是一个意义非凡的科学问题。