The N-end rule pathway is a conserved pathway for the control of protein turnover, through which the clipping or modification of amino acids from the amino-terminus of a protein leads to an interaction with PROTEOLYSIS 6 (PRT6; an N-recognin E3 ligase) and 26S proteasome-mediated proteolysis. Previously, hypoxia (low oxygen) and nitric oxide (NO) were shown to […]
Rice is one of our most important crops, and previous work has indicated that it was domesticated independently in Asia (Oryza sativa) and Africa (Oryza glaberrima). Using archeological approaches, Hilbert et al. for the first time show evidence for domestication of a rice species (Oryza sp.) in the Americas. From excavation sites in Brazil, the […]
Visual and other cues attract pollinators. Bees vision is skewed towards blue colors, but they also visit non-blue flowers. Moyroud et al. looked at how petal surface textures affect bee responses. The authors observed that similar parallel cuticular striations in diverse angiosperm lineages show convergent optical properties, and cause preferential scattering of short-wavelength blue and […]
One of the great questions of biology is how and why C4 photosynthesis pathway evolved independently more than 60 times. The advantages are obvious (increased productivity), but the underlying molecular predisposition to this transition remains poorly defined. Using a comparative transcriptomics approach involving the non-C4 relatives of C4 plants, Moreno-Villena et al. found that the […]
Review: DNA sequencing at 40: past, present and future ($) Shendure et al. provide a superb review of how DNA sequencing technology has changed over the years and how these changes open up new applications. They start with the Maxam and Gilbert chemical cleavage and the Sanger “chain-termination” methods developed in the 1970s, and describe […]
Yesterday I attended a “Careers in Industry” discussion where it was noted that people working in industry often benefit from more structured mentoring programs than are the norm in academia. The lack of formal mentoring programs and mentor training has long been noted as a weakness in the academic training system. One of the panelists recommended that everyone learn […]
Are you interested in science writing? Do you want to help people understand complex scientific issues? Apply for the ASPB/AAAS Mass Media Science & Engineering Fellows Program and learn how to increase public understanding of science and technology. Fellows in the 10-week 2018 summer program will work as reporters, researchers, and production assistants in […]
Peroxisomes are endoplasmic reticulum-derived membrane-enclosed organelles in which many oxidative enzymatic reactions are compartmentalized. These reactions and their products contribute to energy production, detoxification, and signaling. Kao et al. review our understanding of the plant peroxisome, including the role of peroxisome enzymes (and how these nuclear-encoded proteins are targeted to the peroxisome), as well as […]
Another excellent entry in PLOS Computational Biology’s “Ten Simple Rules” series. Read “Ten simple rules for writing a response to reviewers” here. Short version: Rule 1: Provide an overview, then quote the full set of reviews Rule 2: Be polite and respectful of all reviewers Rule 3: Accept the blame Rule 4: Make the response […]