XinMeng Gui: The Plant Cell First Author

XinMeng Gui, first author of “Phytophthora effector hijacks the host pre-mRNA splicing machinery to modulate small RNA and plant immunity”

Current Position: Ph.D. candidate at Shanghai Normal University, Shanghai, China.

Education: Ph.D. in College of life Sciences, Shanghai Normal University.

Non-scientific Interests: Travelling, Cooking.

Brief bio: I started my PhD study in Prof. Yongli Qiao’s laboratory at Shanghai Normal University since 2019. My research mainly focused on the pathogenic mechanism of Phytophthora effectors and followed previous work in Prof. Qiao laboratory. Phytophthora sojae effector PSR1 suppress small RNA accumulation and plant immunity by interacting with the splicing factor Prp16 protein (PINP1) in plants. Our current work further show a clearly molecular mechanism in regulating small RNA and plant immunity through the PSR1 and PINP1 interaction. We demonstrated that the PSR1-PINP1 interaction caused the global alternative splicing (AS) changes, revealed that PSR1 regulates plant immunity and small RNA biogenesis via binding and depressing the splicing and pri-miRNAs binding function of PINP1 protein. Our findings uncover a novel role for PINP1 in regulating sRNA biogenesis and plant immunity

姓名：桂新孟（“疫霉效应子通过劫持宿主pre-mRNA剪接机制来调节sRNA和植物免疫”第一作者）

目前职位：上海师范大学在读博士

教育经历：上海师范大学生命科学学院博士

兴趣爱好：旅行、烹饪

我于2019年开始在上海师范大学乔永利教授实验室攻读博士学位。我的研究主要集中于大豆疫霉效应子的致病机制方面的研究，并延续了乔教授实验室之前的工作。大豆疫霉效应子PSR1通过与植物的剪接因子Prp16蛋白（PINP1）相互作用来抑制了sRNA的积累和植物免疫。我们当前的工作进一步表明了PSR1通过和PINP1的相互作用调控sRNA和植物免疫的一个明确的分子机制。我们发现PSR1和PINP1的相互作用可引起全基因组范围内的可变剪接（AS）变化，揭示了PSR1通过与PINP1蛋白互作和减弱PINP1剪接和pri-miRNAs结合功能来调控植物免疫和sRNA积累。我们的研究发现了PINP1在调控sRNA生物生成和植物免疫方面的一个新机制。