Recognizing Plant Physiology first authors: Yingying Qin

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Yingying Qin, co-first author of Redox-Mediated Endocytosis of a Receptor-Like Kinase during Distal Stem Cell Differentiation Depends on its Tumor Necrosis Factor Receptor Domain

Current Position: Ph.D. State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China

Education: Ph.D. in State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China; B.S. in College of Life Sciences, Shanxi Agricultural University, Taigu, China

Non-scientific Interests: reading, amine, movies

Brief bio: I graduated from Shanxi Agricultural University College of Life Sciences in 2012 and then joined Professor Zhizhong Gong’s research group in the College of Biology of China Agricultural University, where I started my Ph.D. study. My Ph.D. project was the mechanism of ROS homeostasis regulating differentiation of distal stem cells (DSC). We found that the stability of the receptor-like kinase ACR4 is modulated by redox status through endocytosis in root tips. ACR4 with multiple cysteine mutations in the tumor necrosis factor receptor (TNFR) extracellular domain failed to undergo endocytosis. ACR4 with a complete deletion of the TNFR domain was localized directly to endosomes, bypassing the plasma membrane. Both mutations affected DSC differentiation, but not seed filling. Our study uncovers an important biological role of the TNFR domain in redox-mediated endocytosis of ACR4 in root DSC differentiation. Currently, I have received my Ph.D. degree. I hope there will be more discoveries in future scientific research.

 

论文：Redox-Mediated Endocytosis of a Receptor-Like Kinase during Distal Stem Cell Differentiation Depends on its Tumor Necrosis Factor Receptor Domain

姓名：秦迎迎

当前职位：中国农业大学生物学院，博士毕业生

教育经历：2012/09 – 2019/06，中国农业大学生物学院植物生理生化国家重点实验室，植物学专业，理学博士；2008/09 – 2012/06，山西农业大学生命科学学院，生物科学（生物安全方向）专业，理学学士。

兴趣爱好：阅读、动漫、电影

个人简介：2012年从山西农业大学生命科学学院本科毕业后，我有幸加入中国农业大学生物学院巩志忠教授课题组攻读博士学位。在研究生学习期间，我的主要研究内容是ROS稳态对根尖小柱干细胞DSC分化的调控机制。本研究发现了ROS稳态调控DSC分化过程中的重要因子ACR4, ACR4通过胞外的TNFR功能域调控其蛋白的周转, 进而参与ROS稳态对DSC分化的调控。除此之外, 本研究还发现ACR4能够调控PLTs的转录水平和转录后水平以及ROS与生长素信号共同调控DSC分化。这些发现对于进一步理解ROS稳态对植物生长发育的重要性以及ACR4各个功能域的作用有很重要的理论意义。目前，我已获得博士学位，希望能够在未来的科学研究有更多的发现。