Recognizing Plant Cell first authors: Yanrong You
Yanrong You, first author of LEUNIG_HOMOLOG Mediates MYC2-Dependent Transcriptional Activation in Cooperation with the Coactivators HAC1 and MED25
Current Position: Ph.D. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Education: Ph.D. in Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; B.S. in Biotechnology, Shandong Normal University, Jinan, China
Non-scientific Interests: traveling, mountain hiking, reading, movies
Brief bio: I received my bachelor’s degree in Biotechnology from Shandong Normal University in 2011. Then I joined Prof. Chuanyou Li’s lab at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences to start my PhD study. I’m very interested in the jasmonate (JA) signaling pathway and JA-mediated plant defense responses. My PhD project was to investigate the molecular mechanism of hormone-dependent activation of MYC2, which is a master transcriptional factor of JA signaling. We found that Arabidopsis Groucho/Tup1 family protein LEUNIG_HOMOLOG (LUH) activates MYC2-directed transcription of jasmonate-responsive genes via the Mediator subunit MED25 and the histone acetyltransferase HAC1. Interestingly, the function of LUH in regulating jasmonate signaling is distinct from the function of TOPLESS (TPL), another member of the Gro/Tup1 family that represses MYC2-dependent gene expression in the resting stage. Currently, I have just received my PhD degree, and am planning to apply a post-doctoral position to continue my research interests in plant science.
姓名：由艳荣
当前职位：中科院遗传与发育生物学研究所，博士毕业生
教育经历：2011-2019，中科院遗传与发育生物学研究所，发育生物学专业，博士；2007-2011，山东师范大学，生物技术专业，学士
兴趣爱好：旅行、爬山、阅读、看电影
个人简介：2011年从山东师范大学生物技术专业毕业后，我有幸加入中科院遗传与发育生物学研究所李传友研究员课题组攻读博士学位。我们实验室在植物激素茉莉酸调控植物抗性反应的分子机制方面有很好的研究基础，我的课题主要是探究茉莉酸途径核心转录因子MYC2激活下游响应基因表达的分子机制。我们发现拟南芥Groucho (Gro)/Tup1家族成员LEUNIG_HOMOLOG (LUH)正向调控MYC2介导的茉莉酸响应基因的表达。深入的研究发现LUH作为支架蛋白在茉莉酸信号响应过程中通过整合转录中介体亚基MED25和组蛋白乙酰基转移酶HAC1发挥激活作用。之前的研究表明另一个Gro/Tup1家族成员TOPLESS (TPL)在静息状态下抑制MYC2的转录活性，我们的工作发现同为Gro/Tup1家族蛋白的TPL和LUH在茉莉酸信号途径中发挥着截然相反的作用，这拓宽了人们对该家族蛋白作用机制的认识。目前，我已获得博士学位，正在计划申请博士后职位，希望在将来的研究中能有更多新的发现。
