Fabin Yang: The Plant Cell First Author

Fabin Yang, co-first author of “Inhibition of SIZ1-mediated SUMOylation of HOOKLESS1 promotes light-induced apical hook opening in Arabidopsis”

Current Position: Ph.D. candidate, Sichuan University

Education: Master’s degree, Qufu Normal University

Non-scientific Interests: Playing basketball and watching movies

Brief bio: I began my doctoral study in Prof. Dawei Zhang’s research group in 2020, mainly study the molecular mechanism of how SUMOylation regulates plant development. Our study found that the SUMO E3 Ligase SAP AND MIZ1 DOMAIN- CONTAINING LIGASE1(SIZ1) can positively regulate the apical hook development. Moreover, SIZ1 can interact with the HLS1 (HOOKLESS1), a central regulator of apical hook development. SIZ1 mediates the SUMOylation of HLS1, which is crucial for the apical hook development. Upon exposure to the light, HY5 suppresses SIZ1 transcription, decreasing HLS1 SUMOylation and thus initiating the apical hook quickly opening. Our study not only finds a post-translational modification of HLS1, but also reveals a rapid regulatory mechanism of apical hook opening via a SIZ1-mediated HLS1 SUMOylation.

姓名：杨发斌

目前职位：四川大学生命科学学院，在读博士生

教育背景：曲阜师范大学，硕士学位

兴趣爱好：打篮球，看电影

个人简介：我于2020年开始在张大伟教授的课题组攻读博士学位，主要研究类泛素修饰SUMO化调控植物发育的分子机制。我们的研究发现SUMO E3连接酶SAP AND MIZ1 DOMAIN- CONTAINING LIGASE1（SIZ1）可以正向调控顶端弯钩的生长发育，并且SIZ1可与顶端弯钩发育的核心调控因子HLS1（HOOKLESS1）相互作用。SIZ1可以介导HLS1的SUMO化，这对于顶端弯钩的发育至关重要。光照条件下，HY5抑制SIZ1的转录，减弱HLS1的SUMO化修饰，减少寡聚体的形成从而导致顶端弯钩的快速展开。我们的研究不仅发现了HLS1的翻译后修饰，同时也揭示了植物通过SIZ1介导的HLS1的SUMO化修饰调控顶端弯钩发育的分子机制。