Precise integration of large DNA sequences in plant genomes using PrimeRoot editors
Although CRISPR/Cas9 tools have provided new opportunities for genome editing, using these systems to introduce large pieces of DNA has been challenging. A new genome editing technique, “PrimeRoot” (Prime editing-mediated Recombination Of Opportune Targets), was introduced by Sun et al. and shown to precisely insert large DNA donors/cargos in rice without double stranded break intermediates. […]